Related Experiment Video

Updated: Feb 13, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Relation between serum cystatin C level and brachial-ankle pulse wave velocity in Chinese general population

Wei Yang1, Shuyang Zhang2, Shengyu Zhang2

  • 1a China Rehabilitation Research Center , Beijing , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|February 28, 2018
PubMed

Insights

Serum cystatin C levels are linked to arterial stiffness in the Chinese population. This study confirms cystatin C as a predictor of arterial stiffness, even after accounting for other risk factors.

Area of Science:

  • Cardiovascular Health
  • Biomarker Research
  • Public Health

Background:

  • Arterial stiffness is a key indicator of cardiovascular health.
  • Serum cystatin C is emerging as a potential biomarker for various health conditions.
  • Understanding its role in arterial stiffness is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between serum cystatin C levels and arterial stiffness.
  • To determine if this association is independent of common cardiovascular risk factors.
  • To evaluate cystatin C as a predictive marker in the Chinese general population.

Main Methods:

  • A cross-sectional study involving 748 participants from Beijing, China.
  • Measurement of brachial-ankle pulse wave velocity (baPWV) using an automated oscillometric device.
  • Quantification of serum cystatin C concentrations.

Main Results:

  • Serum cystatin C showed a significant positive correlation with brachial-ankle pulse wave velocity (r = 0.251, p < 0.001).
  • This correlation persisted after adjusting for age, BMI, and smoking status.
  • Arterial stiffness parameters were also correlated with BMI, SBP, DBP, TG, TC, and HDL-C.

Conclusions:

  • Serum cystatin C level is independently associated with arterial stiffness in the Chinese general population.
  • Increased serum cystatin C is indicative of heightened arterial stiffness.
  • Cystatin C may serve as a valuable biomarker for assessing arterial stiffness, particularly in individuals with normal renal function.
Abstract

Keywords:
Arterial stiffnessbrachial–ankle pulse wave velocity (baPWV)cystatin Cgeneral population

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