Related Experiment Video
Updated: Feb 13, 2026

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
Published on: January 6, 2023
Phytochemical investigation and biological activities of Echium arenarium (Guss) extracts
Sarra Kefi1, Rym Essid2, Khawla Mkadmini3
1Laboratory of Bioactive Substances, Biotechnology Center of Borj Cedria, BP-901, 2050, Hammam-Lif, Tunisia; Faculty of Sciences Tunis El Manar, University of Tunis EL Manar, 2092, Tunis, Tunisia.
Abstract:
The present work was developed to evaluate the in vitro antioxidant, antibacterial, antileishmanial and cytotoxic activities of Echium arenarium (Guss) extracts, and to analyze their phytochemical composition. The highest content of total phenolic compounds was obtained in the ethyl acetate extract which showed the best DPPH scavenging activity and β-carotene bleaching inhibition (IC50 = 1.1 and 9.94 μg/mL respectively). It also exhibited the highest antibacterial activity against Gram-positive bacteria (L. monocytogenes; S. aureus; MRSA, E. faecalis and B. cereus) and antileishmanial activity against L. major (IC50 = 13.91 ± 0.43 μg/mL) and L. infantum (IC50 = 9.91 ± 0.15 μg/mL). Moreover, the active extract exhibited potent antiamastigote activity (IC50 = 22.48 ± 0.14 μg/mL and 18.59 ± 0.09 μg/mL against L. major and L. infantum respectively). Cytotoxicity studies revealed low toxicity against Raw 264.7 macrophage cell line (IC50 = 145.80 ± 0.84 μg/mL, SI < 10). Luteolin-7-O-glucoside was identified as the major flavonoid component by RP-HPLC analysis. In conclusion, Echium arenarium (Guss) extract was characterized by a wide range of biological activities and could be used as a potential natural anti-infectious drug.
Related Concept Videos
Biological Effects of Radiation
What is Conservation Biology?
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Activation Energy
Biological Influences on Intelligence

