Markers of anaphylaxis - a systematic review
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Updated: Feb 13, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Maria Magdalena Tomasiak-Łozowska1, Maciej Klimek1, Agnieszka Lis1
1Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
Abstract:
Anaphylaxis is defined as severe, life-threatening, systemic or general, immediate reaction of hypersensitivity, with repeatable symptoms caused by the dose of stimulus which is well tolerated by healthy persons. The proper diagnosis, immediate treatment and differential diagnosis are crucial for saving patient's life. However, anaphylaxis is relatively frequently misdiagnosed or confused with other clinical entities. Thus, there is a continuous need for identifying detectable markers improving the proper diagnosis of anaphylaxis. Here we presented currently known markers of anaphylaxis and discussed in more detail the most clinically valuable ones: tryptase, platelet activacting factor (PAF), PAF-acethylhydrolase, histamine and its metabolites.
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