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Mirtazapine-Induced Pancreatitis-A Case Report
Riley D Bowers1,2,3, Sara M Valanejad1, Ashley A Holombo1
1Department of Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC, USA.
Journal of Pharmacy Practice
|March 1, 2018
Summary
Mirtazapine, a medication, can cause dangerously high triglyceride levels leading to acute pancreatitis. Discontinuing mirtazapine and using insulin infusion normalized triglyceride levels and resolved pancreatitis symptoms in a patient.
Area of Science:
- Pharmacology
- Gastroenterology
- Clinical Medicine
Background:
- Acute pancreatitis has multiple causes, including gallstones, alcohol, and certain medications like ACE inhibitors, statins, and diuretics.
- Mirtazapine is known to elevate cholesterol and triglyceride levels, but its role in causing acute pancreatitis is rarely reported.
Observation:
- A 46-year-old African American female presented with acute pancreatitis, initially suspected to be alcohol-induced.
- The patient denied recent alcohol consumption, leading to suspicion of medication side effects.
- Mirtazapine was identified as the probable cause of hypertriglyceridemia-induced pancreatitis.
Findings:
- Discontinuation of mirtazapine and administration of an insulin infusion led to normalization of triglyceride levels.
- The patient's pancreatitis symptoms resolved after triglyceride levels normalized.
Implications:
- This case highlights mirtazapine as a potential cause of drug-induced acute pancreatitis due to hypertriglyceridemia.
- Clinicians should consider mirtazapine in the differential diagnosis of unexplained acute pancreatitis, especially in patients with elevated triglycerides.
- Further research is warranted to understand the mechanisms and incidence of mirtazapine-induced pancreatitis.
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