Related Experiment Video
Updated: Feb 13, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Complete Lower Extremity Revascularization via a Hybrid Procedure for Patients with Critical Limb Ischemia
Toshio Takayama1, Jon S Matsumura1
11 Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Insights
Complete revascularization using hybrid procedures significantly improved limb salvage for critical limb ischemia (CLI) patients. This approach reduced major amputation rates and enhanced amputation-free survival, demonstrating its benefit in treating CLI.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Therapy
Background:
- Complete revascularization (CR) is crucial for treating critical limb ischemia (CLI).
- Hybrid procedures, combining endarterectomy and endovascular treatment, are common for complex lower extremity lesions.
- This study evaluates the efficacy of CR via hybrid procedures for limb salvage in CLI patients.
Purpose of the Study:
- To investigate the effectiveness of complete revascularization achieved by hybrid procedures in limb salvage for patients with critical limb ischemia (CLI).
Main Methods:
- A retrospective analysis of 61 CLI patients (95 limbs) treated with lower extremity hybrid procedures between 2010 and 2016.
- Patients were categorized into complete revascularization (CR, n=37) and incomplete revascularization (IR, n=24) groups.
- Key outcomes analyzed included postoperative ankle-brachial index (ABI), patency rates, and major amputation rates.
Main Results:
- The CR group showed significantly higher postoperative ABIs (0.87 vs. 0.53) and a trend towards lower major amputation rates (2.7% vs. 13%).
- Major amputation-free survival at 3 years was higher in the CR group (97% vs. 81%).
- Despite higher initial limb ischemia severity (Rutherford 5) in the CR group, outcomes were favorable.
Conclusions:
- Complete lower extremity revascularization achieved through hybrid procedures is beneficial for critical limb ischemia (CLI) patients.
- This approach effectively reduces major amputation rates and improves limb salvage.
- Hybrid procedures offer a viable strategy for achieving CR and improving outcomes in CLI.
Background:
Complete revascularization, achieving inline flow to the foot through at least 1 patent tibioperoneal artery, is considered to be desirable for treating critical limb ischemia (CLI). Hybrid procedure, combined femoral endarterectomy and endovascular treatment, is commonly performed on patients with CLI because they often present with complicated lower extremity lesions involving the common femoral artery. This study aimed to investigate the efficacy of complete revascularization (CR) achieved by hybrid procedure on limb salvage in patients with CLI.
Methods:
Between February 2010 and January 2016, 95 limbs (82 patients) were treated by lower extremity hybrid procedure; of these 95 procedures, 61 were for patients with CLI. We defined CR as achieving inline flow to the foot through at least 1 patent tibioperoneal artery. Complete revascularization was performed on 37 limbs, and incomplete revascularization (IR) was performed on 24 limbs. Specific variables, including patient age, male-female ratio, Rutherford classification, preoperative and postoperative ankle-brachial pressure indices (ABIs), follow-up duration (months), primary patency rate, assisted primary patency rate, secondary patency rate, and major amputation rate, were analyzed.
Results:
The mean age was similar between the groups 67.2 years in the CR group and 70.7 years in the IR group ( P = .11). Limb ischemia severity was significantly higher in the CR group: 63% of the patients scored Rutherford 5 in the CR group, compared to 30% in the IR group ( P = .027). Mean postoperative ABI was significantly higher in the CR group (CR: 0.87, IR: 0.53; P = .0001). Major amputation rate was higher in the IR group (CR: 2.7%, IR: 13%; P = .29), and major amputation-free survival rate at 3 years after the index procedure was higher in the CR group (CR: 97%, IR: 81%; P = .054).
Conclusion:
Complete lower extremity revascularization was beneficial for patients with CLI, avoiding major amputation.
Related Concept Videos
Hybrid Zones
Critical Region, Critical Values and Significance Level
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
Hybridization of Atomic Orbitals I
Critical Values
Hybridization of Atomic Orbitals II
Absolute and Local Extreme Values

