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Interim estimate of influenza vaccine effectiveness in hospitalised children, Hong Kong, 2017/18

Susan S Chiu1,2, Mike Y W Kwan2,3, Shuo Feng4

  • 1Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital and Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|March 1, 2018
PubMed

Insights

The 2017/18 influenza vaccine demonstrated 66% effectiveness in preventing hospitalizations in Hong Kong children. This protection was particularly strong against influenza B, showing 65% vaccine effectiveness.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health Surveillance

Background:

  • Influenza poses a significant burden on child health, necessitating ongoing vaccine effectiveness (VE) monitoring.
  • Accurate VE estimates are crucial for informing public health vaccination strategies.
  • The 2017/18 influenza season in Hong Kong required specific VE assessment.

Purpose of the Study:

  • To estimate the influenza vaccine effectiveness (VE) among children hospitalized with febrile acute respiratory illness in Hong Kong during the 2017/18 winter season.
  • To provide timely data on the performance of the influenza vaccine against circulating strains.

Main Methods:

  • A hospital-based, test-negative case-control study design was employed.
  • Data included 1,078 children admitted with febrile acute respiratory illness between December 4, 2017, and January 31, 2018.
  • Influenza testing was performed on all eligible participants.

Main Results:

  • Overall influenza VE was estimated at 66% (95% CI: 43-79).
  • VE against influenza B, the predominant virus (B/Yamagata lineage), was estimated at 65% (95% CI: 40-80).

Conclusions:

  • The influenza vaccine provided substantial protection against hospitalization in children during the 2017/18 season in Hong Kong.
  • The vaccine demonstrated good effectiveness against the circulating influenza B strains, particularly B/Yamagata.

Keywords:
influenza viruspublic healthtest negative designvaccine effectivenessvaccines and immunisationviral infections

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