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Updated: Feb 13, 2026
08:08
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
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Placental pathologic changes and perinatal outcomes in placenta previa
Eun Jung Jung1, Hwa Jin Cho2, Jung Mi Byun3
1Department of Obstetrics and Gynecology, Inje University Busan Paik Hospital, Busan, South Korea.
Placenta
|March 1, 2018
Summary
Placenta previa is linked to larger placentas and more maternal underperfusion, but does not increase neonatal risks. This study highlights placental adaptations in placenta previa pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Pathology
Background:
- Placenta previa involves implantation in the lower uterine segment, potentially causing poor uteroplacental perfusion and adverse neonatal outcomes.
- Abnormal placentation can also lead to severe postpartum hemorrhage.
Purpose of the Study:
- To compare placental histopathology and perinatal outcomes in pregnancies with placenta previa versus controls.
- To investigate the relationship between placental morphology and perfusion in placenta previa.
Main Methods:
- A retrospective case-control study was conducted.
- 93 pregnancies with placenta previa and 81 controls were analyzed between 2011 and 2017.
Main Results:
- Placentas in placenta previa cases showed larger diameters, increased areas, and more marginal cord insertions.
- Histopathology revealed significant associations with maternal underperfusion, including villous infarction and intervillous fibrin deposition.
- The placenta previa group had higher rates of abnormally invasive placenta and postpartum hemorrhage, but no increased neonatal mortality or morbidity.
Conclusions:
- Compensatory placental growth in placenta previa may enhance perfusion despite abnormal implantation.
- Morphological changes in placenta previa appear to maintain adequate uteroplacental-fetal perfusion, preventing adverse neonatal outcomes.
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