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Related Experiment Video

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Employing Aeroponic Systems for the Clonal Propagation of Cannabis
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Subcortical Local Functional Hyperconnectivity in Cannabis Dependence.

Peter Manza1, Dardo Tomasi1, Nora D Volkow2

  • 1National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|March 1, 2018
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Summary

Chronic cannabis abuse (CA) alters brain connectivity in dopamine pathways, particularly in young adults with early initiation. These changes may explain links between cannabis use and psychopathology, including psychosis risk.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Cannabis abuse (CA) is linked to psychopathology, including psychosis and negative emotionality, especially with early initiation.
  • The underlying neurobiological mechanisms remain unclear.
  • Aberrant dopamine signaling is implicated in cannabis-associated psychopathology.

Purpose of the Study:

  • To investigate the association between regular cannabis abuse and altered resting-state functional connectivity in dopamine midbrain-striatal circuits.
  • To explore neurobiological differences related to cannabis use and psychopathology.

Main Methods:

  • Examined resting-state brain activity in subcortical regions of 441 young adults.
  • Included 30 subjects with cannabis abuse (dependence) and 30 matched control subjects.
  • Utilized data from the Human Connectome Project.

Main Results:

  • Cannabis abuse subjects showed increased local functional connectivity density in ventral striatum, midbrain, brainstem, and lateral thalamus compared to controls.
  • These alterations were more pronounced in individuals with earlier cannabis initiation and higher negative emotionality.
  • No significant differences in subcortical volumes were observed.

Conclusions:

  • Chronic cannabis abuse is associated with altered resting-state brain function, particularly in dopaminergic pathways.
  • These neurobiological changes may underlie the link between cannabis use and psychopathology, including psychosis.
  • Findings highlight the role of dopamine pathways in habit formation, reward processing, and cannabis-associated mental health issues.