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Updated: Feb 13, 2026
07:43
Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy
Published on: April 28, 2022
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Photodynamic therapy and diagnosis: Principles and comparative aspects
Jane Dobson1, Genilson Fernandes de Queiroz2, Jon P Golding3
1Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
Veterinary Journal (London, England : 1997)
|March 1, 2018
Summary
Photodynamic therapy (PDT) uses light-activated drugs to treat superficial tumors with minimal toxicity. This review compares PDT applications in human and veterinary medicine, aiming to advance its use in animals.
Area of Science:
- Oncology
- Photochemistry
- Immunology
Background:
- Photodynamic therapy (PDT) is a minimally invasive treatment for superficial tumors.
- It utilizes photosensitizers, oxygen, and light to generate cytotoxic reactive oxygen species (ROS).
- PDT offers excellent tissue healing with minimal scarring, unlike surgery or radiotherapy.
Purpose of the Study:
- To provide a comparative review of current photodynamic therapy literature in human and veterinary medicine.
- To establish a foundation for the future development of PDT in veterinary oncology.
- To highlight PDT's potential in diagnosing and treating various cancers.
Main Methods:
- Review of existing scientific literature on photodynamic therapy.
- Comparative analysis of PDT efficacy and application in human and veterinary patients.
- Examination of photosensitizer properties, including fluorescence for tumor visualization.
Main Results:
- PDT effectively treats superficial tumors in humans and specific conditions in animals (feline SCC, canine neoplasia, equine sarcoids).
- PDT damages tumor microvasculature and stimulates an immune response.
- Photosensitizers aid in tumor visualization, improving surgical accuracy.
Conclusions:
- PDT is a versatile and effective treatment for various cancers in humans and animals.
- Further research and development are needed to expand PDT applications in veterinary medicine.
- PDT's non-invasive nature and diagnostic capabilities make it a promising therapeutic modality.
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