Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.1K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

652
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
652
Anatomy of the Intestines01:23

Anatomy of the Intestines

87.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.9K
Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

2.4K
The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
2.4K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

743
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
743

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

Cephalalgia : an international journal of headache·2026
Same author

Distinct systemic metabolic signatures in premenopausal women with lipedema revealed by composite indices.

Frontiers in endocrinology·2026
Same author

Comparative cardiovascular outcomes of GLP-1 receptor agonists vs. SGLT2 inhibitors in type 2 diabetes: a large-scale real-world cohort analysis.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells.

bioRxiv : the preprint server for biology·2026
Same author

Cardiometabolic and metabolic profiles in irritable bowel syndrome associated with type 2 diabetes.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease.

Nature communications·2026

Related Experiment Video

Updated: Feb 13, 2026

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
07:10

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies

Published on: February 9, 2024

3.8K

The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function.

Christian Sina1, Claudia Kemper2, Stefanie Derer3

  • 1Institute of Nutritional Medicine, Molecular Gastroenterology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; 1st Department of Medicine, Section of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Seminars in Immunology
|March 1, 2018
PubMed
Summary
This summary is machine-generated.

The complement system, part of innate immunity, helps the gut barrier by responding to microbes. Its dysregulation is linked to inflammatory bowel disease (IBD), but its precise role in Crohn's disease and ulcerative colitis needs more study.

Keywords:
Chronic inflammatory bowel diseaseComplement systemCrohn’s diseaseIntestinal epithelial cellsUlcerative colitis

More Related Videos

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
09:24

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model

Published on: February 11, 2021

8.0K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

12.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
07:10

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies

Published on: February 9, 2024

3.8K
Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
09:24

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model

Published on: February 11, 2021

8.0K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

12.8K

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • The complement system is a key part of innate immunity, working alongside Toll-like receptors (TLRs) to detect microbial-associated molecular patterns (MAMPs).
  • Intestinal epithelial cells (IECs) express complement components, crucial for maintaining intestinal barrier function and responding to microbial signals.
  • Imbalances in the intestinal complement system can exacerbate chronic intestinal inflammation, such as inflammatory bowel disease (IBD).

Purpose of the Study:

  • To explore the role of the complement system in intestinal epithelial cells (IECs) and its connection to inflammatory bowel disease (IBD).
  • To investigate how complement activation in IECs influences intestinal barrier function and inflammation.
  • To understand the differential mechanisms of complement expression in IECs between ulcerative colitis (UC) and Crohn's disease (CD).

Main Methods:

  • Review of existing literature on complement system function in the gut.
  • Analysis of complement component expression in intestinal epithelial cells (IECs).
  • Comparison of complement system involvement in mouse models of IBD and human patient data (UC and CD).

Main Results:

  • Mice lacking specific complement components exhibit heightened intestinal inflammation, mirroring IBD phenotypes.
  • Complement system dysregulation is implicated in worsening intestinal inflammation.
  • Distinct mechanisms govern complement expression in IECs in UC versus CD patients.

Conclusions:

  • The complement system plays a critical role in intestinal homeostasis and inflammation.
  • Understanding the specific interactions between IECs, gut bacteria, and complement components is vital for differentiating IBD subtypes.
  • Further research is needed to elucidate these interactions for targeted therapeutic strategies in IBD.