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Updated: Aug 9, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
T8 cell suppression of antigen- and mitogen-induced T4 cell dependent immunoglobulin production
Abstract:
The suppressor effect of T8 cells on antigen-induced, as compared to pokeweed mitogen-induced, T4 cell dependent immunoglobulin (Ig) production by B cells of healthy subjects was studied. The antigens used were purified protein derivative of tuberculin (PPD) and tetanus toxoid (TT). The suppressor effect of T8 cells on IgG, IgM and IgA responses in co-cultures of T4 cells and B cells was significantly stronger in the pokeweed mitogen driven system than in PPD- and TT-driven cultures under the same experimental conditions.
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