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Related Experiment Videos

IgA specific helper factor (alpha HF) in human colostrum.

H Shinmoto, H Kawakami, S Dosako

    Clinical and Experimental Immunology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Human colostrum contains an IgA specific helper factor (alpha HF) that stimulates B cells. This factor promotes IgA secretion, explaining why IgA is the dominant immunoglobulin in colostrum.

    Area of Science:

    • Immunology
    • Human Colostrum Research

    Background:

    • Human colostrum is rich in immunoglobulins, primarily IgA.
    • The specific factors responsible for IgA induction in colostrum are not fully understood.

    Purpose of the Study:

    • To investigate the induction of immunoglobulin secretion by human colostrum.
    • To identify and characterize factors in colostrum that stimulate IgA production.

    Main Methods:

    • Utilized human peripheral blood lymphocytes (PBL) and B lymphoblastoid cells.
    • Stimulated cells with human colostrum and analyzed immunoglobulin secretion.
    • Characterized the IgA specific helper factor (alpha HF) using gel filtration and chromatofocusing.

    Main Results:

    • Colostrum stimulation induced IgA plaque-forming cells, but not IgG or IgM.

    Related Experiment Videos

  • Identified an IgA specific helper factor (alpha HF) in colostrum.
  • Characterized alpha HF with an approximate molecular weight of 80 kD and a PI range of 5.8-6.2.

    • Conclusions:

    • Human colostrum contains an alpha HF that specifically induces IgA secretion.
    • Hypothesize that alpha HF stimulates IgA-committed B cells in the mammary gland to differentiate into dimeric IgA-producing plasma cells.
    • This mechanism explains the predominance of IgA in human colostrum.