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Updated: Feb 13, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Hirschsprung disease (HD) can cause lifelong bowel issues even after childhood surgery. Adults with undiagnosed or post-surgical HD require expert evaluation for persistent defecation disorders.

Keywords:
Hirschsprungcomplicationsconstipationincontinencereoperation

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Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Colorectal Surgery

Background:

  • Hirschsprung disease (HD) is a congenital condition affecting the distal intestinal tract due to absent enteric nervous system elements.
  • While typically diagnosed in infancy via rectal biopsy, some cases present later in life or have persistent issues post-surgery.

Purpose of the Study:

  • To review the long-term outcomes and management of adult patients with Hirschsprung disease.
  • To emphasize the need for multidisciplinary evaluation of persistent defecation disorders in adults with a history of HD.

Main Methods:

  • Review of long-term results of surgical interventions for HD.
  • Discussion of systematic evaluation protocols for adult patients with HD-related defecation disorders.
  • Brief consideration of late-diagnosed HD cases.

Main Results:

  • Despite surgical treatment in infancy, many patients experience ongoing defecation disorders into adulthood.
  • Early diagnosis and surgical correction do not always guarantee perfect long-term functional outcomes.

Conclusions:

  • Adults with Hirschsprung disease require specialized, multidisciplinary assessment for persistent bowel dysfunction.
  • Surgeons managing these patients must possess comprehensive knowledge of HD operations and potential complications.