Related Experiment Video

Updated: Feb 13, 2026

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

5.2K

Reduced anaerobic and aerobic performance in children with primary ciliary dyskinesia

Senem Simsek1, Deniz Inal-Ince2,3, Aslihan Cakmak1

  • 1Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.

European Journal of Pediatrics
|March 1, 2018
PubMed

Insights

Children with primary ciliary dyskinesia (PCD) show reduced anaerobic and aerobic performance. Age independently predicts anaerobic capacity, while gender determines aerobic performance in these children.

Area of Science:

  • Pediatric Pulmonology
  • Exercise Physiology
  • Rare Diseases

Background:

  • Primary ciliary dyskinesia (PCD) is a genetic disorder affecting cilia function, leading to chronic respiratory infections and reduced quality of life.
  • Exercise performance, crucial for daily activities and overall health, is often compromised in chronic pediatric conditions.
  • Limited research exists on the specific impacts of PCD on both anaerobic and aerobic exercise capacities in children.

Purpose of the Study:

  • To investigate and compare anaerobic and aerobic performance in children diagnosed with PCD versus healthy controls.
  • To identify factors influencing anaerobic and aerobic capacity in children with PCD.
  • To establish the early-stage impact of PCD on physical performance.

Main Methods:

  • A cohort of 31 children with PCD and 29 age- and sex-matched healthy controls participated.
  • Evaluations included pulmonary function tests, hand grip strength (HGS), quadriceps strength (QMS), and physical activity assessment.
  • Anaerobic capacity was measured using a muscle power sprint test, and aerobic performance was assessed via the modified shuttle walk test (MSWT).

Main Results:

  • Children with PCD exhibited significantly lower pulmonary function, HGS, QMS, mean anaerobic power (MAP), and MSWT distance compared to healthy subjects.
  • In PCD patients, MAP was independently predicted by age.
  • Aerobic performance (MSWT distance) in PCD was independently predicted by gender, with males performing better.

Conclusions:

  • Both anaerobic and aerobic exercise capacities are significantly impaired in children with PCD from early stages.
  • Age is a key determinant of anaerobic performance, while gender influences aerobic performance in PCD.
  • Further research is needed to explore the role of skeletal muscle characteristics and sex-based body composition differences in PCD-related exercise capacity deficits.

Keywords:
ChildrenExercise testMuscle strengthPrimary ciliary dyskinesiaPulmonary function test

More Related Videos

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.6K
Culturing and Maintaining Clostridium difficile in an Anaerobic Environment11:13

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

40.1K

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.3K
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
395
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.4K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
328
Adaptations that Reduce Water Loss01:57

Adaptations that Reduce Water Loss

Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
28.3K
Role of Reduced Coenzymes NADH and FADH₂01:29

Role of Reduced Coenzymes NADH and FADH₂

The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
17.1K