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[Enterobacteriaceae susceptibility to piperacillin/tazobactam in a Chilean pediatric hospital]

Juan Rojas De la Vega1, Dona Benadof2, Abigail Veas2

  • 1Universidad de Chile, Santiago, Chile.

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|March 1, 2018
PubMed
Abstract

Insights

Enterobacteriaceae isolates in Chilean pediatric patients show high susceptibility to piperacillin/tazobactam (PIP/TAZO). This indicates effective treatment options for these gram-negative rod infections in this population.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Susceptibility

Background:

  • Enterobacteriaceae are gram-negative rods causing human infections.
  • Previous studies reported 79.4% susceptibility to piperacillin/tazobactam (PIP/TAZO) in Klebsiella pneumoniae in Chilean pediatric hospitals.
  • Limited data exists on PIP/TAZO susceptibility for other Enterobacteriaceae species in this demographic.

Purpose of the Study:

  • To determine the in vitro susceptibility of Enterobacteriaceae to PIP/TAZO in pediatric patients in Chile.
  • To provide current data on antimicrobial resistance patterns for Enterobacteriaceae in a pediatric setting.

Main Methods:

  • A prospective, descriptive study was conducted from January 2013 to August 2014.
  • Enterobacteriaceae isolates were obtained from patients at
  • Hospital de niños Roberto del Río
  • .
  • Susceptibility to PIP/TAZO was determined using the E-test® gradient diffusion method, adhering to 2014 CLSI standards.

Main Results:

  • 163 cases were analyzed, with a median age of 4 years and 15 days; 70.6% were female.
  • Urine cultures constituted 79.7% of the samples.
  • Overall, 95.1% (n=155) of Enterobacteriaceae isolates demonstrated susceptibility to PIP/TAZO, with 1.8% (n=3) showing intermediate susceptibility.

Conclusions:

  • Enterobacteriaceae isolates from this pediatric population exhibit high in vitro susceptibility to PIP/TAZO.
  • This high susceptibility may be attributed to limited prior exposure to this antibiotic and low rates of extended-spectrum beta-lactamase (ESBL) producing organisms in pediatric infections.

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