Related Experiment Video

Updated: Sep 5, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

[Polyomavirus in immunocompromised patients: the South America's situation]

Francisca Jung1, M José Martínez2, Aldo Gaggero2

  • 1Universidad de Los Andes, Santiago, Chile.

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|March 1, 2018
PubMed

Insights

Researchers are investigating human polyomaviruses (PyV) and their link to diseases, especially in immunocompromised individuals. This review highlights current knowledge and research gaps, particularly in South America, to encourage further study of these infectious agents.

Area of Science:

  • Virology
  • Infectious Diseases
  • Immunology

Background:

  • Human polyomaviruses (PyV) are a significant concern, with ongoing efforts to identify new types associated with pathologies.
  • Despite 15 identified PyV types, many lack clear disease associations, particularly in immunocompromised patients.
  • Research on PyV in South America is insufficient, necessitating a systematic review of existing knowledge.

Purpose of the Study:

  • To consolidate current knowledge on human polyomaviruses (PyV).
  • To explore the relationship between PyV and various human organ systems, with a focus on immunocompromised individuals.
  • To identify and highlight existing research data on PyV within South America.

Main Methods:

  • Systematic review of scientific literature on human polyomaviruses.
  • Analysis of published data focusing on PyV in South America.
  • Compilation of information on PyV-associated pathologies in different human systems.

Main Results:

  • Identified 15 human polyomavirus types, with many lacking definitive disease associations.
  • Highlighted a significant knowledge gap in PyV research within South America.
  • Documented the association of certain PyV with pathologies in immunocompromised patients.

Conclusions:

  • Further research is crucial to understand the role of human polyomaviruses (PyV) in disease.
  • There is a need to expand PyV research, especially in South America, to address existing knowledge gaps.
  • Encouraging the study of PyV infections is essential for improving diagnostics and treatment in vulnerable populations.

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...