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Mechanism-Based Condition Screening for Sustainable Catalysis in Single-Electron Steps by Cyclic Voltammetry
Theresa Liedtke1, Peter Spannring1, Ludovico Riccardi1
1Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard Domagk-Straße 1, 53121, Bonn, Germany.
Angewandte Chemie (International Ed. in English)
|March 1, 2018
Summary
A new cyclic voltammetry method screens catalysts for Cp2TiX-catalyzed reactions. This approach optimizes conditions for Cp2TiX generation and radical arylations, saving time and resources.
Area of Science:
- Organometallic Chemistry
- Electrochemistry
- Catalysis
Background:
- Cp2TiX complexes are active catalysts but exist in equilibrium with inactive species.
- Understanding this equilibrium is crucial for optimizing catalytic reactions.
Purpose of the Study:
- Introduce a cyclic voltammetry screening method for Cp2TiX-catalyzed reactions.
- Investigate the influence of additives on electrochemically generated Cp2TiX.
- Determine optimal conditions for Cp2TiX-catalyzed reactions.
Main Methods:
- Cyclic voltammetry for catalyst screening.
- Mechanism-based approach to study equilibria.
- Electrochemical generation of active catalyst species.
Main Results:
- Thioureas and ureas are efficient in generating Cp2TiX in THF.
- The equilibrium position between Cp2TiX and [Cp2TiX2]- was determined.
- Reaction conditions for bulk electrolysis and radical arylations were identified without performing the reactions.
Conclusions:
- The developed method is time- and resource-efficient.
- This approach is valuable for designing single-electron step catalytic reactions.
- The study provides insights into Cp2TiX-catalyzed processes.
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