Related Experiment Video
Updated: Feb 13, 2026
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
11.9K
Ion-modified nanoparticles induce different apatite formation in cervical dentine.
M Toledano1, M Toledano-Osorio1, A L Medina-Castillo2
1Dental Materials Section, Faculty of Dentistry, Granada, Spain.
International Endodontic Journal
|March 1, 2018
Summary
Zinc-nanoparticle gels significantly enhanced hydroxyapatite crystal formation and size in dentine remineralization. Calcium-nanoparticle gels produced more amorphous minerals, while doxycycline-nanoparticles showed poor crystal development.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Nanotechnology in Dentistry
Background:
- Cervical dentine erosion poses a significant clinical challenge.
- Remineralization strategies aim to restore mineral content and structural integrity.
- Nanoparticle-based gels offer potential for targeted dentine repair.
Purpose of the Study:
- To evaluate the impact of four nanogel solutions on dentine crystallinity and ultrastructure.
- To assess the remineralization efficacy of zinc, calcium, and doxycycline-loaded nanoparticles.
- To investigate the potential of nanogels for occluding dentine tubules and promoting mineralization.
Main Methods:
- Citric acid-etched dentine specimens were treated with experimental nanogels.
- Nanoparticles incorporated zinc, calcium, or doxycycline.
- Dentine surface analysis utilized X-ray diffraction and transmission electron microscopy.
Main Results:
- Zinc-nanoparticle (Zn-NPs) gels yielded hydroxyapatite with superior crystallographic maturity and size.
- Dentine treated with Zn-NPs gels exhibited diverse apatite crystal morphologies (polyhedral, plate-like, drop-like).
- Calcium-nanoparticle (Ca-NPs) gels resulted in more amorphous mineral phases compared to Zn-NPs.
- Doxycycline-nanoparticles (Doxy-NPs) led to small crystallites with compromised crystallinity and stability.
Conclusions:
- Newly formed hydroxyapatite, both crystalline and amorphous, was observed with Zn-NPs and Ca-NPs gels.
- Nanogels facilitate the formation of diverse hydroxyapatite crystal shapes, including rounded, plate-like, needle-like, polyhedral, and cubic.
- Zn-NPs demonstrated the most promising results for dentine remineralization regarding crystal quality and morphology.
Related Concept Videos
03:45Formation of Complex Ions
26.3K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.3K
03:24Common Ion Effect
47.1K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
47.1K
03:11Precipitation of Ions
30.3K
Predicting Precipitation
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
30.3K
01:19Ion Channels
91.5K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.5K
03:27Ions and Ionic Charges
79.5K
In ordinary chemical reactions, the nucleus — which contains the protons and neutrons of each atom and thus identifies the element — remains unchanged. Electrons, however, can be added to atoms by transfer from other atoms, lost by transfer to other atoms, or shared with other atoms. The transfer and sharing of electrons among atoms govern the chemistry of the elements. During the formation of some compounds, atoms gain or lose electrons to form electrically charged particles called...
79.5K
02:54Ions as Acids and Bases
26.7K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
26.7K