Aromatase in normal and diseased liver
Keigo Murakami1, Shuko Hata2, Yasuhiro Miki3
1Department of Pathology, Tohoku University Hospital, 1-1 Seiryou-machi, Aoba-ku,Sendai 980-8574, Japan, Phone: +81-22-7177440, Fax: +81-22-7177449.
Hormone Molecular Biology and Clinical Investigation
|March 1, 2018
Summary
Hepatocellular carcinoma (HCC) development may involve sex hormones. This study found higher aromatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in hepatitis B virus (HBV) infected livers, suggesting increased estrogen synthesis in hepatocytes.
Area of Science:
- Hepatology
- Endocrinology
- Oncology
Background:
- Sex hormones, including androgens and estrogens, are implicated in hepatocellular carcinoma (HCC) development.
- Aromatase status in diseased human liver remains largely uncharacterized.
Purpose of the Study:
- To investigate the expression of aromatase and 17β-hydroxysteroid dehydrogenase (17β-HSD) types 1 and 2 in various liver diseases.
- To explore the potential correlation between hepatitis B virus (HBV) infection and in situ estrogen synthesis.
Main Methods:
- Immunolocalization of aromatase, 17β-HSD type 1, and 17β-HSD type 2 was performed on 155 liver tissue samples.
- Samples included normal liver, nonalcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), biliary atresia, alcoholic hepatitis, hepatitis C virus (HCV), HCV sustained virologic response (HCV-SVR), hepatitis B virus (HBV), HBV sustained virologic response (HBV-SVR), and infants.
Main Results:
- Significantly higher aromatase immunoreactivity scores were observed in HBV, HBV-SVR, and infant liver tissues compared to normal liver.
- 17β-HSD type 1 scores were significantly lower in most etiologies, except for HBV and infants, compared to normal liver.
- 17β-HSD type 2 scores were significantly lower in NASH compared to normal liver.
Conclusions:
- Elevated aromatase and 17β-HSD type 1 immunoreactivity in HBV-infected livers suggests a link between HBV and enhanced in situ estrogen synthesis within hepatocytes.
- These findings highlight a potential role for sex hormone metabolism in HBV-associated liver disease progression.
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