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Related Experiment Videos

Piroxicam-induced photosensitive dermatitis.

K J McKerrow, D E Greig

    Journal of the American Academy of Dermatology
    |December 1, 1986
    PubMed
    Summary

    Piroxicam can cause photosensitivity, with positive photopatch tests in affected patients. Some individuals developed persistent light reactions or hand dermatitis following exposure.

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    Area of Science:

    • Dermatology
    • Photobiology
    • Toxicology

    Background:

    • Photosensitivity reactions are adverse drug reactions.
    • Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID).
    • Drug-induced photosensitivity can manifest in various ways.

    Purpose of the Study:

    • To investigate piroxicam as a cause of photosensitivity.
    • To evaluate photopatch testing in diagnosing piroxicam-induced photosensitivity.
    • To identify potential co-reactants or associated conditions.

    Main Methods:

    • Photopatch testing with serial dilutions of piroxicam (2%, 5%, 20%).
    • Standard patch testing.
    • Clinical assessment of photosensitivity and dermatitis.

    Main Results:

    • Eleven patients presented with photosensitivity attributed to piroxicam.
    • All six photopatch-tested patients showed positive reactions to piroxicam.
    • The same group also demonstrated patch test positivity to thimerosal.
    • Three patients developed persistent light reactions.
    • Two additional patients developed persistent hand dermatitis.

    Conclusions:

    • Piroxicam is a confirmed cause of photosensitivity.
    • Photopatch testing is a valuable diagnostic tool for piroxicam-induced photosensitivity.
    • Thimerosal may be a co-reactant in some cases.
    • Persistent light reactions and hand dermatitis are potential sequelae.

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