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Updated: Feb 13, 2026

Phase Contrast and Differential Interference Contrast DIC Microscopy
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Development of molecular-selective differential interference contrast microscopy utilizing stimulated Raman

Motohiro Banno, Takayuki Kondo, Hiroharu Yui

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    A new differential interference contrast (DIC) stimulated Raman scattering (SRS) microscope images nanoscale structures. This DIC-SRS microscopy effectively visualizes buried interfaces with molecular specificity.

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    Area of Science:

    • Optics and Photonics
    • Materials Science
    • Microscopy

    Background:

    • Stimulated Raman Scattering (SRS) microscopy provides molecular contrast.
    • Differential Interference Contrast (DIC) microscopy offers topographical information.
    • Combining these techniques can enhance imaging capabilities for complex interfaces.

    Purpose of the Study:

    • To develop a novel microscope integrating DIC and SRS.
    • To demonstrate its capability in imaging nanoscale structures and buried interfaces.
    • To assess its potential for molecular-selective topographical imaging.

    Main Methods:

    • Development of a hybrid DIC-SRS microscope setup.
    • Overlapping a coherent SRS signal with a reference beam.
    • Correlating signal intensity with height differences for topographical mapping.
    • Imaging silicon (Si) surfaces and liquid crystal-buried Si interfaces.

    Main Results:

    • Successfully imaged Si surfaces with structures ranging from 50-350 nm.
    • Obtained clear DIC-SRS images of Si surfaces buried by liquid crystal.
    • Demonstrated effective visualization of the Si-liquid crystal interface using both Si and liquid crystal SRS signals.
    • Confirmed the capability to image structures with heights below tens of nanometers.

    Conclusions:

    • The developed DIC-SRS microscope is effective for high-resolution imaging.
    • It enables molecular-selective topographical imaging of buried interfaces.
    • This technique shows promise for analyzing nanoscale structures in optically transparent media.