Traumatic brain injury pharmacological treatment: recommendations

Renato Anghinah1, Robson Luís Oliveira de Amorim2, Wellingson Silva Paiva2

  • 1Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurologia, Serviço de Reabilitação Cognitiva pós-TCE, São Paulo SP Brasil.

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Cholinergic Antagonists: Pharmacological Actions

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Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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A drug’s dosage and pharmacokinetic properties determine how quickly it acts, how intense its effects are, and how long it lasts. Higher doses increase drug concentration at receptor sites, producing a hyperbolic curve when pharmacologic response is plotted against drug dose. Converting this scale to a log-linear format results in a sigmoidal curve, better representing dose–response relationships.For drugs following a one-compartment model, the pharmacologic response is directly...
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