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Updated: Feb 13, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Correlation between GDF-15 gene polymorphism and the formation of collateral circulation in acute ST-elevation
Xiao-Ping Chen1, Xiao-Sen Shang1, Yan-Bin Wang1
1Department of Cardiology, Taiyuan Central Hospital, Taiyuan, Shanxi, China.
Insights
The growth differentiation factor 15 (GDF-15) -3148C/G polymorphism is linked to ST-elevation myocardial infarction (STEMI). The CC genotype specifically promotes the formation of collateral circulation in STEMI patients.
Area of Science:
- Cardiovascular Genetics
- Molecular Cardiology
- Genetic Epidemiology
Background:
- The formation of collateral circulation is crucial for mitigating myocardial damage in ST-elevation myocardial infarction (STEMI).
- Genetic factors influencing collateralization in STEMI remain an active area of research.
- Growth differentiation factor 15 (GDF-15) has been implicated in cardiovascular disease pathogenesis.
Purpose of the Study:
- To investigate the association between the GDF-15 -3148C/G gene polymorphism and the development of collateral circulation in patients with acute STEMI.
- To determine if this GDF-15 polymorphism is a risk factor for STEMI in the Han population of Taiyuan.
- To explore the role of GDF-15 polymorphism in collateral formation within STEMI patients.
Main Methods:
- A case-control study involving 92 STEMI patients and 56 healthy controls, confirmed by coronary angiography.
- STEMI patients were stratified into groups with (collateral) and without (non-collateral) significant coronary collateral circulation based on Rentrop's grading.
- Genotyping for the GDF-15 -3148C/G polymorphism was performed using Polymerase Chain Reaction (PCR) and DNA sequencing.
Main Results:
- A significant difference in the distribution of GDF-15 -3148C/G genotypes (CC and GC) and allele frequencies was observed between STEMI patients and controls (p=0.009 and p=0.016, respectively).
- The CC genotype was identified as a risk genotype for STEMI, with an odds ratio of 2.660.
- Within the STEMI cohort, the CC genotype was significantly associated with the promotion of collateral circulation formation (p=0.048), although allele frequencies did not differ significantly between collateral and non-collateral subgroups.
Conclusions:
- The GDF-15 -3148C/G polymorphism is correlated with the formation of collateral circulation in patients experiencing acute ST-elevation myocardial infarction.
- This genetic variation may play a role in the angiogenic response following myocardial infarction.
Objective:
To explore the correlation between growth differentiation factor 15 (GDF-15) -3148C/G polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction (STEMI) in Han population of Taiyuan area.
Method:
The present study included 92 STEMI patients and 56 normal controls based on coronary angiography; STEMI group was divided into collateral group and non-collateral group according to Rentrop's grading method. Polymerase chain reaction (PCR) and DNA sequencing methods were used to detect and analyze the GDF-15 -3148C/G polymorphism in all participants.
Results:
There was significant difference in GDF-15 -3148C/G CC and GC distribution between STEMI group and control group (p=0.009); the allele frequencies between these two groups were also significant different (p=0.016); and the risk genotype for STEMI was CC with increased OR=2.660. For STEMI group, GDF-15 -3148C/G CC and GC distribution was also significantly different between patients with and without collateral (p=0.048), and CC genotype significantly promote the formation of collateral circulation. However, there were no significant differences in allele frequencies between these two subgroups of STEMI.
Conclusion:
There was correlation between GDF-15-3148C/G polymorphism and the formation of collateral circulation in patients with acute STEMI.
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