Sclerosing cholangitis from intraarterial floxuridine

Area of Science:

• Gastroenterology and Hepatology
• Oncology
• Interventional Radiology

Background:

• Biliary strictures mimicking sclerosing cholangitis are a known complication.
• Intraarterial chemotherapy is used for liver metastases from colorectal cancer.

Observation:

• A patient receiving intraarterial chemotherapy for liver metastases developed segmental intrahepatic biliary strictures.
• These strictures were located away from known metastatic sites.

Findings:

• The patient survived for 3-4 years with documented liver metastases.
• Progressive portal hypertension, hypersplenism, and fat malabsorption were observed.
• A review of previously reported cases is included.

Implications:

• Chemotherapy-induced biliary strictures are a significant concern in liver cancer treatment.
• These strictures can lead to severe, long-term complications.
• Further research is needed to understand and manage this adverse event.