Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Interfacial Electrochemical Methods: Overview01:06

Interfacial Electrochemical Methods: Overview

914
Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current...
914
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

813
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
813
DNA as a Genetic Template02:05

DNA as a Genetic Template

28.0K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.0K
DNA Topoisomerases02:02

DNA Topoisomerases

35.9K
Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
35.9K
DNA Helicases00:55

DNA Helicases

24.2K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmaceutical applications of framework nucleic acids.

Acta pharmaceutica Sinica. B·2022
Same author

Programmable DNA Hydrogels as Artificial Extracellular Matrix.

Small (Weinheim an der Bergstrasse, Germany)·2022
Same author

Ionic Current Fluctuation and Orientation of Tetrahedral DNA Nanostructures in a Solid-State Nanopore.

Small (Weinheim an der Bergstrasse, Germany)·2022
Same author

Benzyl-rich ligand engineering of the photostability of atomically precise gold nanoclusters.

Chemical communications (Cambridge, England)·2022
Same author

Catalytic Nucleic Acids for Bioanalysis.

ACS applied bio materials·2022
Same author

Impact of Graphene Exposure on Microbial Activity and Community Ecosystem in Saliva.

ACS applied bio materials·2022
Same journal

Immunometabolomics Applied to Physical Exercise: Accomplishments and New Directions for Health Improvement.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Carbon Nanofibers for Mass-Producible Electrochemical Transducers for Point-of-Care Testing.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Application of Ambient Ionization Mass Spectrometry to the Analysis of <i>Cannabis</i>.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

From Function to Single Cells: Analytical Innovations in Islet Biology and Diabetes Research.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Quantum Cascade Laser-Based Vibrational Circular Dichroism Imaging for Chiral Biosensing.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen
17:16

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Published on: June 3, 2018

14.4K

DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development.

Dekai Ye1,2, Xiaolei Zuo1,3, Chunhai Fan1

  • 1Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility (SSRF), Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|March 1, 2018
PubMed
Summary
This summary is machine-generated.

DNA nanotechnology enhances biosensor performance by engineering interfaces. This approach addresses key challenges in sensitivity and specificity for medical and environmental applications.

Keywords:
DNA nanotechnologybiosensorframework nucleic acidinterfacial engineeringself-assembly

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

685
Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

34.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen
17:16

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Published on: June 3, 2018

14.4K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

685
Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

34.7K

Area of Science:

  • Biomimetic analytical tools
  • Nanotechnology
  • Interfacial engineering

Background:

  • Biosensors face performance limitations (sensitivity, specificity, speed, reproducibility) hindering real-world applications.
  • Effective interfacial engineering is crucial for biosensor development but faces challenges in controlling DNA assembly.
  • DNA nanotechnology offers novel strategies for precise control over biological interfaces.

Purpose of the Study:

  • To present a DNA nanotechnology-enabled interfacial engineering approach for improving biosensor performance.
  • To review challenges in biosensing interfaces and the role of DNA assembly.
  • To highlight the application of DNA nanostructures in engineering biological interfaces for biosensing.

Main Methods:

  • Review of recent advancements in DNA nanotechnology.
  • Focus on framework nucleic acids for interface engineering.
  • Discussion of implementing DNA nanostructures in biosensor design.
  • Exploration of detecting various biomarkers including nucleic acids, proteins, and small molecules.

Main Results:

  • DNA nanostructures, particularly framework nucleic acids, enable precise engineering of biosensing interfaces.
  • This approach shows promise in overcoming limitations in biosensor sensitivity, specificity, and speed.
  • Successful application in detecting a wide range of biomarkers.

Conclusions:

  • DNA nanotechnology provides a powerful platform for interfacial engineering in biosensors.
  • This strategy significantly improves biosensor performance and broadens their applicability.
  • Promising future directions for DNA nanotechnology in biosensing and related fields.