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Updated: Feb 13, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
Published on: February 25, 2007
Embryonic Stem Cells and Infertility
Nahid Lorzadeh1, Nastaran Kazemirad2
1Faculty of Medicine, Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract:
Embryonic stem cells (ESCs) have the ability to differentiate into several cell lineages and self-renew. Through a spontaneous process, ESCs can differentiate into germ cells of various stages, partly due to their self-renewal ability and their microenvironment culture. Human and mouse ESC differentiation into putative primordial germ cells (PGCs) has been demonstrated by several studies; in fact, derivation of functional mouse male gametes has also been reported. However, the exact underlying mechanisms are yet to be understood properly, and as such clinical applications of ESC-derived PGC remains controversial. Nonetheless, this technique can still serve as a potential treatment option for infertility. This review centers on the available reports on the possible application of ESC for infertility treatment.
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