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A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail
Published on: February 3, 2016
Outcomes of arteriovenous fistula for hemodialysis in octogenarian population
Cemal Kocaaslan1, Tamer Kehlibar2, Mehmet Yilmaz2
11 Department of Cardiovascular Surgery, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.
Insights
Arteriovenous fistula creation is a viable option for octogenarians undergoing hemodialysis, showing acceptable survival rates and patency comparable to younger patients. Age alone should not preclude fistula use in selected elderly individuals.
Area of Science:
- Vascular Surgery
- Nephrology
- Geriatric Medicine
Background:
- Current guidelines recommend arteriovenous fistula (AVF) for hemodialysis access.
- Optimal AVF access in octogenarians remains unclear.
- This study evaluates AVF outcomes in elderly patients.
Purpose of the Study:
- To assess the death-censored cumulative patency rate of AVFs in octogenarians.
- To document complications associated with AVF in this age group.
- To analyze patient survival rates following AVF creation.
Main Methods:
- Retrospective review of 70 octogenarian patients undergoing 88 AVF interventions.
- Analysis of postoperative complications.
- Calculation of death-censored cumulative patency rates using Kaplan-Meier method for 24 months.
Main Results:
- 6- to 24-month death-censored cumulative patency rates ranged from 63.6% to 41.4%.
- Primary failure rate was 40.9%.
- 12- and 24-month patient survival rates were 68.5% and 58.5%, respectively.
Conclusions:
- AVF in octogenarians demonstrates comparable patency to non-elderly populations.
- Two-year survival rates are acceptable in this cohort.
- AVF should be considered for selected octogenarians, with age not being an absolute contraindication.
Abstract:
Introduction Guidelines have been recommending the use of arteriovenous fistula among the hemodialysis population, but no clear conclusion has emerged with regard to the adequate access type in octogenarians. In this paper, the outcomes of arteriovenous fistula in octogenarian cohort were presented for death-censored cumulative patency rate, complications, and patients' survival rate. Methods A retrospective review of 88 consecutive arteriovenous fistula interventions in 70 octogenarian patients were performed at one referral institution between January 2010 and June 2014. The patients' records were analyzed and postoperative complications were documented. Death-censored cumulative arteriovenous fistula patency rates were calculated, and Kaplan-Meier method was used to analyze patient survival for 24 months.
Findings:
Eighty-eight arteriovenous fistula constructions and six salvage procedures were performed in 70 octogenarians. Fifty-four (61.3%) forearm and 34 (38.7%) upper arm fistulas were created. All types of fistulas had 6-, 12-, 18-, and 24-month death-censored cumulative patency rates of 63.6%, 58.3%, 48.8%, and 41.4%, respectively. The primary failure rate was 40.9%. A total of 15 complications were documented as edema, hematoma/bleeding, infection, distal ischemia, and venous aneurysm, all of which had been treated. Patient survival rates for 12 and 24 months were 68.5% and 58.5%, respectively.
Discussion And Conclusion:
This analysis regarding arteriovenous fistula in octogenarian end-stage renal disease patients figured out equal death-censored cumulative patency compared to nonelderly, and two-year survival rate was acceptable. This study strengthens the argument that arteriovenous fistula should be the best proper choice in selected octogenarians; older age only should not be considered as an absolute contraindication for arteriovenous fistula creation in octogenarians; and patient-based approach should be applied.
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