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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
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Engineered Non-Viral Gene Vectors for Combination Cancer Therapy: A Review.

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    Engineered non-viral gene vectors show promise for gene therapy, overcoming challenges in safe and efficient delivery. Advances in polymer gene carriers offer expanded treatment options for various diseases.

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    Area of Science:

    • Biotechnology
    • Gene Therapy
    • Polymer Science

    Background:

    • Gene therapy holds significant potential for treating diseases, spurred by recent FDA approvals.
    • Developing safe and efficient gene delivery vectors is a critical challenge hindering clinical success.
    • Current non-viral gene vectors face limitations due to lower efficiency and biological barriers.

    Purpose of the Study:

    • To explore the advancements in engineered non-viral gene delivery vectors for gene therapy.
    • To address the challenges associated with traditional non-viral gene vectors.
    • To highlight the potential of polymer gene carriers in overcoming existing limitations.

    Main Methods:

    • Development of engineered polymer-based gene carriers.
    • Investigating methods to enhance efficiency and overcome biological barriers.
    • Incorporating therapeutic molecules and targeted delivery strategies.

    Main Results:

    • Engineered polymer gene carriers demonstrate expanding functionalities.
    • Success observed in combining therapeutic molecules with targeted delivery approaches.
    • Overcoming limitations of charge interactions and biological instability.

    Conclusions:

    • Polymer gene-carrier vectors represent a promising advancement in gene therapy.
    • These vectors offer a broader range of new treatment possibilities for diseases.
    • Continued development is crucial for realizing the full potential of non-viral gene delivery.