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Published on: June 17, 2025
Association between urticaria and nematode infections.
Paola L Minciullo1, Antonio Cascio2, Sebastiano Gangemi1
1From the School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino," Messina, Italy.
Urticaria can be linked to nematode infections, though a direct cause is often unclear. Physicians should consider parasite testing based on individual patient factors, not routine screening.
Area of Science:
- Medical Parasitology
- Dermatology
- Immunology
Background:
- The link between parasitic infections and urticaria has been recognized for over a century.
- Prevalence of parasitic infections in chronic urticaria (CU) ranges widely, and urticaria can occur in patients with parasitosis.
- Nematodes are a significant group of helminths affecting millions globally.
Purpose of the Study:
- To compile and review existing literature and case reports on urticaria associated with nematode infections.
Main Methods:
- A comprehensive literature search was conducted across scientific databases.
- The search covered publications from January 1960 to May 2017.
Main Results:
- Numerous nematode species, including Anisakis simplex, Ascaris spp., and Toxocara spp., have been linked to urticaria and/or angioedema.
- Pathogenesis remains largely unexplained; some cases involve direct presence of the worm, while others suggest IgE-mediated allergic reactions.
- Associations for some nematodes were anecdotal, with limited reported cases.
Conclusions:
- Establishing a definitive causal link is challenging, often relying on symptom improvement post-treatment.
- Helminths are a rare cause of isolated urticaria.
- Parasitosis is considered a rare cause of CU in developed countries; parasite testing is a physician's decision based on patient specifics.
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