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Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy
Kozo Yoshikawa1, Mitsuo Shimada2, Jun Higashijima2
1Department of Surgery, The University of Tokushima, Tokushima, Japan yoshikawa.kozo@tokushima-u.ac.jp.
Aim:
To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy.
Patients And Methods:
The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed.
Results:
The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant.
Conclusion:
Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT.
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