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Related Concept Videos

Classifying Matter by Composition03:35

Classifying Matter by Composition

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Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
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A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
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Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
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Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
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Related Experiment Video

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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Gut microbial composition in patients with psoriasis.

Francisco M Codoñer1, Ana Ramírez-Bosca2,3, Eric Climent1

  • 1Lifesequencing S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif 2, 46980, Paterna, Valencia, Spain.

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|March 2, 2018
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Summary

This study identifies a unique "psoriatic core intestinal microbiome" in plaque psoriasis patients, distinct from healthy individuals. Certain gut microbiome enterotypes correlate with increased bacterial translocation and inflammation in psoriasis.

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Area of Science:

  • Microbiology
  • Dermatology
  • Gastroenterology

Background:

  • The gut microbiome's influence on intestinal and dermatological diseases like atopic dermatitis is increasingly recognized.
  • Limited data exists on the gut microbiome's role in psoriasis, a prevalent skin condition.
  • Understanding the gut microbiome in psoriasis is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the gut microbiome composition in patients with plaque psoriasis.
  • To explore the relationship between gut microbiome profiles and bacterial translocation in psoriatic patients.
  • To identify a potential

Main Methods:

  • Prospective study involving 52 plaque psoriasis patients (Psoriasis Area and Severity Index score ≥6).
  • Gut microbiome analysis using 16S rRNA massive sequencing on the Illumina MiSeq platform.
  • Average of 85,000 sequences analyzed per sample to determine microbial composition and enterotypes.

Main Results:

  • Identification of a distinct

Conclusions:

  • Psoriatic patients exhibit a unique gut microbiome composition ('psoriatic core intestinal microbiome') compared to healthy individuals.
  • Enterotype 2 in psoriatic patients is associated with a significantly higher incidence of bacterial translocation and elevated inflammatory markers.
  • These findings suggest a link between specific gut microbiome profiles, bacterial translocation, and inflammation in psoriasis.