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Updated: Feb 13, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
A curious case of central odontogenic fibroma: A novel perspective
Chetana Chandrashekar1, Subhalakshmi Sen2, Venkadasalapathi Narayanaswamy3
1Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Abstract:
We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C-kit and mast cells in the pathogenesis of COF is described.
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