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Keratinizing pleomorphic adenoma: An unusual case report
Aanchal Tandon1, Rohit Jaiswal1, Safia Siddiqui1
1Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Pleomorphic adenoma, a common salivary gland tumor, can show extensive squamous metaplasia. This rare variant with keratin cysts may mimic malignancy, requiring careful microscopic evaluation.
Area of Science:
- Oral pathology
- Surgical pathology
- Head and neck oncology
Background:
- Pleomorphic adenoma (PA) is the most common benign salivary gland neoplasm.
- PAs display diverse histological features, including differentiation into various cell types.
- Squamous metaplasia is an uncommon feature in PAs.
Observation:
- This report details a case of pleomorphic adenoma in a minor salivary gland of the hard palate.
- The tumor presented as a slowly enlarging mass.
- Microscopic examination revealed extensive squamous metaplasia and keratin cyst formation.
Findings:
- The extensive squamous metaplasia and keratin cysts in this PA case mimicked malignant salivary gland tumors.
- Differential diagnosis included mucoepidermoid carcinoma and squamous cell carcinoma.
- Histological features confirmed the benign nature of the pleomorphic adenoma despite its unusual presentation.
Implications:
- Recognizing this rare variant of pleomorphic adenoma is crucial for accurate diagnosis.
- Extensive squamous metaplasia can lead to misdiagnosis if not carefully evaluated.
- This case highlights the importance of thorough histopathological examination in salivary gland tumors.
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