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The Natural Compound Dansameum Reduces foam Cell Formation by Downregulating CD36 and Peroxisome

Kang-Seo Park1, Sang Hyun Ahn2, Kang Pa Lee3

  • 1Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Pharmacognosy Magazine
|March 2, 2018
PubMed

Insights

Dansameum extract (DSE) shows anti-atherosclerotic effects by reducing foam cell formation. DSE down-regulates CD36 and PPAR-γ expression, lowering lipid content in cells and animal models.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Molecular Biology

Background:

  • Atherosclerosis is a leading cause of death, with foam cell formation being a critical step.
  • Foam cell formation is mediated by CD36 and peroxisome proliferator-activated receptor gamma (PPAR-γ) expression.

Purpose of the Study:

  • To investigate the anti-atherosclerotic potential of Dansameum extract (DSE).
  • To determine if DSE down-regulates CD36 and PPAR-γ expression in oxidative low-density lipoprotein (oxLDL)-treated RAW264.7 cells and in ApoE Knockout (ApoE-/-) mice.

Main Methods:

  • DSE was prepared from Salvia miltiorrhiza, Amomum xanthioides, and Santalum album.
  • Immunohistochemistry and RT-PCR were used to analyze protein and mRNA expression.
  • Experiments were conducted on oxLDL-treated RAW264.7 cells and ApoE-/- mice fed a high-fat diet.

Main Results:

  • DSE significantly reduced foam cell formation in both in vitro and in vivo models.
  • DSE treatment decreased CD36 and PPAR-γ expression in oxLDL-stimulated RAW264.7 cells and ApoE-/- mice.
  • DSE regulated heme oxygenase-1 (HO-1) expression and reduced cellular lipid content.

Conclusions:

  • DSE exhibits anti-atherosclerotic properties.
  • DSE effectively regulates foam cell formation by modulating key molecular targets.
  • DSE may serve as a potential therapeutic agent for atherosclerosis.
Abstract

Keywords:
CD36Dansameumfoam cellheme oxygenase-1peroxisome proliferator-activated receptor gamma

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