pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design
Ghulam Abbas1,2, Muhammad Hanif1, Mahtab Ahmad Khan1
1Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Designed Monomers and Polymers
|March 2, 2018
Summary
Alginate raft tablets were developed for controlled release of pantoprazole sodium sesquihydrate (PSS). The optimized formulation demonstrated excellent raft properties and 98% drug release in simulated gastric fluid.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Pantoprazole sodium sesquihydrate (PSS) is a proton pump inhibitor used to treat acid-related gastrointestinal disorders.
- Effective drug delivery systems are crucial for optimizing PSS therapeutic efficacy and patient compliance.
Purpose of the Study:
- To develop and optimize alginate raft-forming tablets for controlled release of pantoprazole sodium sesquihydrate (PSS).
- To characterize the physical and performance attributes of the developed PSS-loaded alginate rafts.
Main Methods:
- Box-Behnken design was employed to optimize 15 formulations based on independent and dependent variables.
- Rafts were evaluated for strength, thickness, resilience, acid neutralizing capacity, and floating characteristics.
- Dissolution studies were conducted in simulated gastric fluid (pH 1.2).
- Characterization of PSS, polymers, and rafts utilized Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), and Differential Scanning Calorimetry (DSC).
Main Results:
- The optimized formulation (AR9) exhibited desirable raft properties: strength (7.43 ± 0.019 g), thickness (5.8 ± 0.245 cm), and resilience (>480 min).
- Acid neutralizing capacity was 11.2 ± 1.01 meq, and buffering capacity was 6.5 ± 0.56 meq.
- Dissolution studies showed 98% cumulative PSS release, following first-order kinetics with non-Fickian diffusion (n > 0.45).
- FTIR, XRD, and DSC confirmed the absence of drug-excipient interactions and the crystalline nature of PSS.
Conclusions:
- Alginate raft tablets provide a suitable platform for the controlled release of pantoprazole sodium sesquihydrate.
- The optimized formulation (AR9) demonstrates promising characteristics for effective gastrointestinal drug delivery.
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