Dealing a Neonate with CHARGE Syndrome:Anaesthesia perspective of perioperative care

Area of Science:

• Genetics and Developmental Biology
• Pediatric Surgery
• Clinical Case Reports

Background:

• CHARGE syndrome is a rare genetic disorder characterized by multiple congenital anomalies.
• Key features include coloboma, heart defects, atresia choanae, growth and genital abnormalities, and ear abnormalities.
• The presentation and severity of CHARGE syndrome vary significantly among affected individuals.

Observation:

• This report focuses on a neonate diagnosed with CHARGE syndrome.
• The neonate presented with choanal atresia, a significant airway obstruction.
• Management involved surgical intervention under general anesthesia with invasive monitoring.

Findings:

• Successful surgical repair of choanal atresia was performed in the neonate with CHARGE syndrome.
• The procedure utilized general anesthesia and invasive monitoring, crucial for managing complex pediatric cases.
• This highlights the feasibility of surgical correction for specific CHARGE syndrome manifestations.

Implications:

• Successful surgical intervention for choanal atresia can improve outcomes for neonates with CHARGE syndrome.
• This case underscores the importance of multidisciplinary care and advanced monitoring in managing complex congenital conditions.
• Further research into surgical techniques and long-term outcomes for CHARGE syndrome patients is warranted.