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Updated: Feb 13, 2026

Murine Model of Wound Healing
Published on: May 28, 2013
Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
Luying Huang1,2, Yi Wang1,3, Hua Liu4
1First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Abstract:
Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, migration and tube formation in endothelial cells, and protects endothelial cells against apoptosis. Local injection of HMW-HA promotes wound healing by increasing angiogenesis in old rats. HMW-HA increases the phosphorylation of Src, ERK and AKT, leading to increased angiogenesis, suggesting that local injection of HMW-HA promotes wound healing in elderly patients.
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