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Author Spotlight: RNAi Inheritance and ChIP in C. elegans
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Transgenerational epigenetics and environmental justice.

Mark A Rothstein1, Heather L Harrell2, Gary E Marchant3

  • 1Institute for Bioethics, Health Policy and Law, University of Louisville School of Medicine, 501 East Broadway #310, Louisville, KY 40202, USA.

Environmental Epigenetics
|March 2, 2018
PubMed
Summary
This summary is machine-generated.

Transgenerational epigenetic inheritance from environmental exposures like pesticides remains unproven. Without compelling evidence of inherited epigenetic harm, new environmental justice policies are unlikely, even for vulnerable populations.

Keywords:
distributive justiceenvironmental justiceepigeneticshazardous exposurestransgenerational epigenetics

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Area of Science:

  • Environmental epigenetics
  • Toxicology
  • Environmental Justice

Background:

  • Acquired epigenetic modifications in humans and their transmission across generations are not definitively established.
  • Environmental exposures, including pesticides, lead, and diesel exhaust, disproportionately affect vulnerable populations.
  • The concept of environmental justice seeks equitable distribution of environmental benefits and burdens.

Purpose of the Study:

  • To examine the potential for transgenerational epigenetic inheritance from environmental exposures.
  • To explore the implications of such inheritance for environmental justice principles and policies.
  • To assess whether compelling evidence of epigenetic harms would necessitate new environmental regulations.

Main Methods:

  • Review of scientific literature on epigenetic inheritance and environmental exposures.
  • Analysis of three hazardous substances: pesticides, lead, and diesel exhaust.
  • Application of environmental justice theories (Rawls's justice as fairness, Sen/Nussbaum's capabilities approach).

Main Results:

  • Suggestive evidence exists for environmental exposures influencing epigenetic modifications.
  • Current scientific evidence for transgenerational epigenetic inheritance in humans is not definitive.
  • Existing environmental justice frameworks may not be significantly altered without concrete proof of inherited epigenetic harm.

Conclusions:

  • A heightened societal obligation to protect vulnerable populations from epigenetic harms is considered.
  • Compelling evidence of transgenerational epigenetic harms is unlikely to drive new policies invoking environmental justice.
  • The lack of definitive proof limits the impetus for policy changes focused on preventing epigenetic harms.