Related Experiment Video
Updated: Feb 13, 2026

09:15
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
1.3K
Pre-transplant ventricular assist device explant
Espeed Khoshbin1, Stephan Schueler1
1The Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK.
Annals of Cardiothoracic Surgery
|March 2, 2018
Summary
Explanting a left ventricular assist device (LVAD) with the heart requires careful planning during LVAD implantation, pre-transplant assessment, and the heart transplant surgery itself for optimal outcomes.
Area of Science:
- Cardiovascular Surgery
- Mechanical Circulatory Support
Background:
- Explantation of left ventricular assist devices (LVADs) can be complex, even for experienced surgeons.
- A systematic approach is crucial for safe removal of LVADs during heart transplantation.
Purpose of the Study:
- To describe a standardized technique for explanting LVADs along with the heart.
- To provide guidance applicable to contemporary implantable mechanical assist devices.
Main Methods:
- Preparation during LVAD implantation: positioning driveline and outflow graft away from the sternum.
- Pre-transplant assessment: utilizing CT scans and ultrasound imaging.
- Surgical technique: careful dissection, off-pump procedures, and potential use of peripheral cardiopulmonary bypass.
Main Results:
- The described technique facilitates safe explantation of LVADs and the heart.
- Key steps include meticulous dissection, strategic cannulation, and precise removal of cardiac structures.
Conclusions:
- Safe LVAD explantation is achievable through meticulous planning and execution at distinct surgical stages.
- The technique ensures adequate cuffs for subsequent anastomosis during heart transplantation.
Related Concept Videos
pre-mRNA Processing
57.6K
In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
57.6K
Pre-mRNA Processing: Modification of pre-mRNA Ends
15.7K
In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
15.7K
Chromatin Structure Regulates pre-mRNA Processing
8.3K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
8.3K
Mnemonic Devices
446
Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
446
Non-ohmic Devices
1.5K
In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
1.5K
Pre-mRNA Processing: RNA Splicing
7.0K
7.0K

