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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
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Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
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[Pyroptosis and stroke].

Biao Tang1, Chang-Qing Deng2

  • 1Medical School, Hunan University of Chinese Medicine, Changsha 410028, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|March 2, 2018
PubMed
Summary
This summary is machine-generated.

Pyroptosis, an inflammatory cell death process, contributes to brain injury after stroke. Inhibiting this process offers a potential therapeutic strategy for stroke treatment.

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Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Pyroptosis is inflammatory programmed cell death mediated by caspases.
  • It plays a role in infectious and nervous system diseases.
  • Canonical and non-canonical inflammasome pathways regulate pyroptosis.

Purpose of the Study:

  • To review the relationship between pyroptosis and stroke.
  • To highlight pyroptosis as a therapeutic target for stroke.

Main Methods:

  • Literature review on pyroptosis and stroke.
  • Analysis of canonical inflammasome pathway activation in stroke.

Main Results:

  • Canonical inflammasome pathway activation exacerbates brain injury post-stroke.
  • Inhibition of inflammasome components (caspase-1, IL-1β, IL-18) ameliorates brain injury.

Conclusions:

  • The canonical inflammasome pathway is implicated in post-stroke brain injury.
  • Targeting pyroptosis presents a promising therapeutic avenue for stroke.