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Published on: April 25, 2012
Analysis of a Minimally Invasive Intracranial Pressure Signals During Infusion at the Subarachnoid Spinal Space of
G Frigieri1, R A P Andrade2, C C Wang2
1Braincare, São Carlos, SP, Brazil. g.frigieri@gmail.com.
Objective:
We developed a new minimally invasive method for intracranial pressure monitoring (ICPMI). The objective of this project is to verify the similarities between the ICPMI and the invasive method (ICPInv), for different components of the intracranial pressure signal-namely, the mean value (trend) as well as its pulsatile component.
Materials And Methods:
A 9 kg anesthetized pig was used for simultaneous ICP monitoring with both methods. ICP was increased by performing ten infusions of 6 ml 0.9% saline into the spinal subarachnoid space, using a catheter implanted in the lumbar region. For correlation analysis, the signals were decomposed into two components-trend and pulsatile signals. Pearson correlation coefficient was calculated between ICPInv and ICPMI.
Results:
During the infusions, the correlation between the pulsatile components of the signals was above 0.5 for most of the time. The signal trends showed a good agreement (correlation above 0.5) for most of the time during infusions.
Conclusions:
The ICPMI signal trends showed a good linear agreement with the signal obtained invasively. Based on the waveform analysis of the pulsatile component of ICP, our results indicate the possibility of using the minimally invasive method for assessing the neuroclinical state of the patient.
Insights
A new minimally invasive intracranial pressure monitoring (ICPMI) method shows promising results. It accurately reflects both the trend and pulsatile components of intracranial pressure compared to invasive methods.
Area of Science:
- Biomedical Engineering
- Neurosurgery
- Medical Devices
Background:
- Intracranial pressure monitoring (ICPMI) is crucial for managing neurological conditions.
- Traditional invasive ICP monitoring carries risks.
- A minimally invasive alternative is needed.
Purpose of the Study:
- To validate a novel minimally invasive ICPMI method.
- To compare ICPMI with invasive ICP monitoring (ICPInv).
- To assess both trend and pulsatile components of the ICP signal.
Main Methods:
- Simultaneous ICP monitoring in an anesthetized pig model using ICPMI and ICPInv.
- ICP elevation via controlled saline infusions.
- Signal decomposition into trend and pulsatile components for correlation analysis.
Main Results:
- The pulsatile components of ICPMI and ICPInv showed correlation coefficients above 0.5.
- Signal trends from ICPMI demonstrated good agreement with ICPInv (correlation > 0.5).
- High correlation was maintained throughout the infusions.
Conclusions:
- The minimally invasive ICPMI method shows good linear agreement for signal trends.
- Waveform analysis of the pulsatile component suggests ICPMI can assess patient neuroclinical status.
- ICPMI offers a viable alternative to invasive ICP monitoring.
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