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ICP Monitoring and Phase-Contrast MRI to Investigate Intracranial Compliance
A Lokossou1,2, O Balédent3,4, S Garnotel3,4
1Research team BioFlowImage, University of Picardie Jules Verne, Amiens, France. armelle.lokossou@etud.u-picardie.fr.
Acta Neurochirurgica. Supplement
|March 2, 2018
Summary
Intracranial compliance in hydrocephalus patients is heterogeneous and lower than expected at rest. This novel measurement, combining ICP monitoring and PCMRI, may improve patient selection for shunt surgery.
Area of Science:
- Neuroscience
- Medical Imaging
- Biomedical Engineering
Background:
- Intracranial pressure (ICP) monitoring measures pressure amplitude.
- Phase-contrast magnetic resonance imaging (PCMRI) quantifies blood and cerebrospinal fluid (CSF) flows.
- Hydrocephalus presents challenges in assessing intracranial dynamics.
Purpose of the Study:
- To investigate intracranial compliance at rest in hydrocephalus patients.
- To combine baseline ICP monitoring and PCMRI for novel assessment.
- To explore a new parameter for improving shunt surgery selection.
Main Methods:
- ICP monitoring quantified basal ICP (ΔICP_rest) in 33 patients.
- PCMRI assessed total cerebral blood flow (tCBF), blood volume change (SVblood), and CSF volume change (CSV).
- Global intracranial volume change (ΔIVC) and compliance (C_rest = ΔIVC/ΔICP_rest) were calculated.
Main Results:
- Resting ICP (ΔICP_rest) was 2.41 ± 1.21 mmHg.
- Calculated compliance (C_rest) was 0.23 ± 0.15 mL/mmHg.
- Significant relationships were found between SVblood and CSV, and SVblood and tCBF.
Conclusions:
- Intracranial compliance amplitude is heterogeneous and lower than expected in suspected hydrocephalus patients.
- This novel parameter offers complementary information to conventional infusion tests.
- The findings may enhance patient selection for shunt surgery.
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