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Related Experiment Video

Updated: Feb 13, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System

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Updates on Primary Central Nervous System Lymphoma.

Lauren R Schaff¹, Christian Grommes^2,3

¹Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Current Oncology Reports

|March 2, 2018

Summary

Primary central nervous system lymphoma (PCNSL) is a rare brain cancer. Treatment involves methotrexate-based chemotherapy, high-dose chemotherapy, and potentially radiation, with new immunotherapies emerging for relapsed cases.

Keywords:

PCNSL Primary CNS lymphoma Primary central nervous system lymphoma Treatment

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Area of Science:

Neuro-oncology
Hematology
Oncology

Background:

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy.
Limited randomized trials contribute to varied management approaches in the oncologic community.

Purpose of the Study:

To review recent literature on PCNSL.
To guide current clinical practice for PCNSL management.

Main Methods:

Review of recent literature on PCNSL presentation, workup, and management.
Discussion of induction and consolidation therapy strategies.
Exploration of treatment for relapsed and refractory disease.

Main Results:

Methotrexate-based chemotherapy is a standard induction therapy.
High-dose chemotherapy with or without stem cell rescue and whole brain radiation therapy (WBRT) are consolidation options.
Immunotherapy and targeted treatments show promise for recurrent/refractory PCNSL.

Conclusions:

PCNSL management lacks consensus and requires individualized treatment plans.
Consideration of neurotoxicity risk is crucial in treatment decisions.
Novel strategies are under development, and clinical trial enrollment is encouraged.