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Nalidixic acid and lactic acidosis.

P J Phillips, A G Need, D W Thomas

Australian and New Zealand Journal of Medicine

|December 1, 1979

Summary

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Nalidixic acid can cause severe lactic acidosis, a potentially fatal condition. This drug may impair lactate metabolism, raising concerns for its use in susceptible patients.

Area of Science:

Pharmacology
Toxicology
Metabolic Disorders

Background:

Nalidixic acid is an antibiotic historically used for urinary tract infections.
Lactic acidosis is a serious medical condition characterized by the buildup of lactate in the bloodstream.

Observation:

A fatal case of lactic acidosis was reported in a patient undergoing nalidixic acid therapy.
Studies in healthy volunteers indicated that nalidixic acid impairs lactate metabolism.

Findings:

Nalidixic acid is associated with severe acidosis.
The drug interferes with the body's ability to metabolize lactate.

Implications:

Caution is advised when prescribing nalidixic acid, particularly in patients at risk of drug accumulation or lactic acidosis.

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Further research may be warranted to elucidate the precise mechanisms of nalidixic acid-induced lactic acidosis.

Consideration should be given to alternative therapies in vulnerable patient populations.