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Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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Duplication of Chromatin Structure02:05

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The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
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Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Interphase00:54

Interphase

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The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
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Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Appendiceal duplication: a new case.

Wissem Triki, Ahmed Itaimi, Imed Abbassi

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    This summary is machine-generated.

    Duplication of the vermiform appendix is a rare congenital anomaly. Surgeons must remain vigilant for this condition during appendectomies to ensure accurate diagnosis and prevent surgical errors.

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    Area of Science:

    • Gastroenterology
    • Surgical Anatomy

    Background:

    • Vermiform appendix duplication is an exceptionally rare congenital anomaly.
    • Fewer than 100 cases have been documented globally.
    • Diagnosis is often incidental during emergency appendectomies for suspected appendicitis.

    Observation:

    • A woman presented with symptoms consistent with acute appendicitis.
    • Surgical exploration revealed the presence of a double appendix.
    • This highlights a rare anatomical variation mimicking common surgical emergencies.

    Findings:

    • The case confirmed a rare instance of appendix duplication.
    • The anomaly presented with typical signs of acute appendicitis, leading to surgical intervention.
    • Diagnostic vigilance is crucial for identifying such rare malformations.

    Implications:

    • Highlights the importance of surgeon awareness regarding rare anatomical variations.
    • Emphasizes the need for careful intraoperative examination to avoid misdiagnosis.
    • Underscores potential clinical and medico-legal ramifications of overlooking such anomalies.