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Complement system activation in obstructive sleep apnea.

Peter Horvath1, David L Tarnoki2, Adam D Tarnoki2

  • 1Department of Pulmonology, Semmelweis University, Budapest, Hungary.

Journal of Sleep Research
|March 2, 2018
PubMed
Summary
This summary is machine-generated.

The complement system, specifically C3a, is activated in obstructive sleep apnea (OSA), correlating with disease severity. This finding suggests a role for complement activation in OSA pathophysiology.

Keywords:
apneaco-morbiditiesinflammationsleep

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Area of Science:

  • Immunology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is linked to systemic inflammation.
  • The role of the complement system in OSA pathophysiology remains uninvestigated.

Purpose of the Study:

  • To investigate the involvement of effector complement components (C3a, C5a, SC5b-9) in obstructive sleep apnea.
  • To correlate complement factor levels with OSA severity and clinical variables.

Main Methods:

  • Plasma levels of C3a, C5a, and SC5b-9 were measured using ELISA in 50 OSA patients and 26 controls.
  • Blood samples were collected in the evening and morning.
  • Complement factor levels were compared between groups and correlated with clinical data.

Main Results:

  • Plasma C3a concentrations were significantly elevated in OSA patients compared to controls at both evening and morning time points (p < 0.05).
  • C5a and SC5b-9 levels did not differ significantly between OSA patients and controls.
  • Elevated C3a levels showed a direct correlation with OSA severity and were associated with male gender, weight, BMI, hypertension, high C-reactive protein, and low HDL cholesterol.

Conclusions:

  • The complement system is activated in obstructive sleep apnea.
  • Activated C3a is correlated with OSA severity and associated clinical factors.
  • These findings suggest a potential role for the complement system in the pathophysiology of OSA.