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Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Molecular mechanism and therapy application of necrosis during myocardial injury
Tao Xu1, Wei Ding2, Muhammad Akram Tariq1
1Center for Regenerative Medicine, Institute for Translational Medicine, Qingdao University, Qingdao, China.
Abstract:
Necrosis is an ancient topic which gains new attraction in the research area these years. There is no doubt that some necrosis can be regulated by genetic manipulation other than an accidental cell death resulting from physical or chemical stimuli. Recent advances in the molecular mechanism underlying the programmed necrosis show a fine regulation network which indicates new therapy targets in human diseases. Heart diseases seriously endanger our health and have high fatality rates in the patients. Cell death of cardiac myocytes is believed to be critical in the pathogenesis of heart diseases. Although necrosis is likely to play a more important role in cardiac cell death than apoptosis, apoptosis has been paid much attention in the past 30 years because it used to be considered as the only form of programmed cell death. However, recent findings of programmed necrosis and the related signalling pathways have broadened our horizon in the field of programmed cell death and promote new pharmacological application in the treatment of heart diseases. In this review, we summarize the advanced progress in these signalling pathways and discuss the pathos-physiological relevance and therapeutic implication of targeting necrosis in heart diseases treatment.
Insights
Programmed necrosis, a regulated cell death, is crucial in heart disease. Targeting necrosis pathways offers new therapeutic strategies for cardiovascular conditions.
Area of Science:
- Cardiovascular Research
- Cellular Biology
- Molecular Medicine
Background:
- Necrosis, a form of cell death, is increasingly recognized as a regulated process.
- Programmed necrosis plays a critical role in the pathogenesis of heart diseases.
- Apoptosis has historically received more attention than necrosis in cardiac cell death research.
Purpose of the Study:
- To review recent advances in the molecular mechanisms of programmed necrosis.
- To discuss the pathophysiological relevance of necrosis in heart diseases.
- To explore the therapeutic implications of targeting necrosis pathways for cardiovascular disease treatment.
Main Methods:
- Literature review of programmed necrosis signalling pathways.
- Analysis of molecular mechanisms underlying necrosis in cardiac myocytes.
- Discussion of current and potential therapeutic strategies targeting necrosis.
Main Results:
- Programmed necrosis involves a complex regulatory network.
- Necrosis is a significant contributor to cardiac myocyte death in heart diseases.
- Emerging signalling pathways in programmed necrosis present novel therapeutic targets.
Conclusions:
- Targeting programmed necrosis offers promising new avenues for treating heart diseases.
- Understanding necrosis mechanisms is vital for developing effective cardiovascular therapies.
- Further research into necrosis signalling pathways can lead to innovative pharmacological applications.
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