Related Experiment Video
Updated: Aug 6, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
[Stroke, platelet activating factor and receptor antagonists]
Zhi-Guo Wang1, Dan-Qiao Wang1, Yue Jiao1
1Beijing Key Laboratory of Basic Research on Prevention and Treatment of Major Diseases by Traditional Chinese Medicine, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Abstract:
Stroke is an acute cerebrovascular disease with high morbidity, disability and mortality. The prevention and treatment conditions for stroke is severe all over the world. Antiplatelet aggregation is an effective treatment. Platelet activation factor (PAF) is another important medium in mediating platelet aggregation, which plays an important role in the pathogenesis of stroke. In recent years, PAF receptor antagonists have attracted international attention in the field of stroke prevention and treatment. In this review, we would summarize the classification, mechanism and drug characteristics of PAF receptor antagonists in order to provide the valuable guidance and direction for clinical medicine and research.
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