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Ceftolozane/tazobactam: place in therapy.
Daniele Roberto Giacobbe1, Matteo Bassetti2, Francesco Giuseppe De Rosa3
1a Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l'Oncologia and Department of Health Sciences , University of Genoa , Genoa , Italy.
Expert Review of Anti-Infective Therapy
|March 2, 2018
Summary
Ceftolozane/tazobactam is a new antibiotic effective against resistant bacteria like MDR P. aeruginosa and ESBL-producers. It offers a carbapenem-sparing option for complicated infections, including cIAI and cUTI.
Area of Science:
- Pharmacology and Infectious Diseases
- Antimicrobial Therapy
Background:
- Ceftolozane/tazobactam (C/T) combines a novel cephalosporin with a beta-lactamase inhibitor.
- It shows activity against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and multi-drug resistant (MDR) Pseudomonas aeruginosa.
Purpose of the Study:
- To delineate the place in therapy of Ceftolozane/tazobactam.
- To review antimicrobial and pharmacological properties and clinical study results.
Main Methods:
- Review of antimicrobial properties.
- Analysis of pharmacological properties.
- Evaluation of clinical study outcomes.
Main Results:
- Ceftolozane/tazobactam is approved for complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI).
- It is valuable for severe infections caused by MDR P. aeruginosa.
- It serves as a carbapenem-sparing alternative for infections caused by ESBL-producers.
Conclusions:
- Ceftolozane/tazobactam is a key therapeutic option for specific resistant infections.
- Off-label use reporting is crucial to expand evidence and clinician confidence.
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