Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cluster Sampling Method01:20

Cluster Sampling Method

14.9K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
14.9K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.3K
Conserved Binding Sites01:49

Conserved Binding Sites

5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.4K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.4K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

116.0K
Overview
116.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erenumab and OnabotulinumtoxinA in Chronic Migraine: A Comparative Analysis.

European journal of neurology·2026
Same author

Is achieving higher standards in real-world migraine care feasible with anti-CGRP monoclonal antibodies preventive therapies?: Insights from the EUREkA cohort.

Cephalalgia : an international journal of headache·2026
Same author

Efficacy, IHS Guideline Adherence, and Methodological Quality of Noninvasive Neuromodulation Clinical Trials in Migraine and Cluster Headache: A Systematic Review.

European journal of neurology·2026
Same author

Consistency of response to rimegepant for the acute treatment of migraine among real-world users - findings from the prospective observational CONFIDENCE study.

The journal of headache and pain·2026
Same author

Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine - data from the REFINE study.

Cephalalgia : an international journal of headache·2026
Same author

Brain structural MRI changes before and after 6 months of preventive treatment with erenumab and onabotulinumtoxinA in migraine.

The journal of headache and pain·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Chronic graft-versus-host disease.

Nature reviews. Disease primers·2026
Same journal

Atopic dermatitis.

Nature reviews. Disease primers·2026
Same journal

Osteomyelitis.

Nature reviews. Disease primers·2026
Same journal

Tinnitus.

Nature reviews. Disease primers·2026
Same journal

Post-traumatic stress disorder.

Nature reviews. Disease primers·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K

Cluster headache.

Arne May1, Todd J Schwedt2, Delphine Magis3

  • 1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

Nature Reviews. Disease Primers
|March 2, 2018
PubMed
Summary
This summary is machine-generated.

Cluster headache is a severe, one-sided pain syndrome with autonomic symptoms. Research implicates the hypothalamus in its pathophysiology, leading to new treatments.

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K
Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K
Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.8K

Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Background:

  • Cluster headache is characterized by excruciating, unilateral head pain and ipsilateral cranial autonomic symptoms.
  • Attacks typically last 15-180 minutes, with pain severity often described as worse than childbirth.
  • Recent advances highlight the hypothalamus's role in generating pain and autonomic features.

Purpose of the Study:

  • To summarize the current understanding of cluster headache pathophysiology.
  • To review diagnostic approaches for cluster headache.
  • To outline recent advancements in treatment strategies.

Main Methods:

  • Literature review focusing on recent research in cluster headache.
  • Analysis of pathophysiological mechanisms involving the hypothalamus and related neural systems.
  • Evaluation of diagnostic criteria and treatment options.

Main Results:

  • The hypothalamus is identified as a key generator of cluster headache symptoms.
  • Connections between the hypothalamus, trigeminovascular system, and parasympathetic nervous system are implicated.
  • Effective treatments for acute attacks and preventive strategies, including pharmacotherapy and neuromodulation, have been developed.

Conclusions:

  • Understanding cluster headache pathophysiology has significantly advanced, implicating central brain structures.
  • Accurate diagnosis relies on symptom-based criteria and exclusion of other headache types.
  • Progress in treatment offers improved management for cluster headache patients.